Scid adenosine deaminase12/27/2023 ![]() In the monomer form, the enzyme is a polypeptide chain, folded into eight strands of parallel α/β barrels, which surround a central deep pocket that is the active site. ĪDA exists in both small form (as a monomer) and large form (as a dimer-complex). However, the full physiological role of ADA is not yet completely understood. Its primary function in humans is the development and maintenance of the immune system. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. positive regulation of alpha-beta T cell differentiationĬrystal structure of plasmodium yoelii adenosine deaminase (py02076)Īdenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme ( EC 3.5.4.4) involved in purine metabolism.positive regulation of germinal center formation.negative regulation of leukocyte migration.negative regulation of inflammatory response.positive regulation of smooth muscle contraction.purine ribonucleoside monophosphate biosynthetic process.regulation of circadian sleep/wake cycle, sleep.positive regulation of B cell proliferation.positive regulation of T cell activation.regulation of cell-cell adhesion mediated by integrin.negative regulation of adenosine receptor signaling pathway.negative regulation of mature B cell apoptotic process.negative regulation of apoptotic process.negative regulation of thymocyte apoptotic process.positive regulation of T cell receptor signaling pathway.positive regulation of calcium-mediated signaling.positive regulation of T cell differentiation in thymus. ![]() negative regulation of circadian sleep/wake cycle, non-REM sleep.positive regulation of T cell differentiation.
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